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Lapatinib (lapatinib) - is an anticancer drug that interferes with the growth of intracellular tyrosine kinase. Used to treat breast cancer in women.
Lapatinib (lapatinib) - is an anticancer drug that interferes with the growth of intracellular tyrosine kinase. Used to treat breast cancer in women. In combination with capecitabine, it is prescribed for a common and / or metastatic breast tumor, when the previous treatment did not produce a result (using anthracyclines, taxanes and trastuzumab). When a hormone-sensitive breast tumor can be administered simultaneously with an aromatase inhibitor (letrozole), this combination contributes to an increase in the survival rate and a reduction in the risk of disease progression in the future. Also, during clinical studies, it was possible to establish that taking Lapatinib and improves the quality and duration of life of patients. Buy Lapatinib Price Lapatinib
Inside It is necessary to carry out reception of Lapatinib once a day all dose entirely. Reduce the intervals between doses can not be. When you skip the dose, you should wait for the next medication.
The size of the dose depends on the disease. In patients with a common and / or metastatic breast tumor, it is 1250 mg simultaneously with capecitabine 2000 mg, and with a hormone-sensitive tumor 1500 mg / day, together with 2.5 mg aromatase inhibitor.
Lapatinib therapy is carried out exclusively under the supervision of a physician with experience in the use of anticancer drugs.
The course of taking Lapatinib a should be accompanied by periodic checks of the patient’s left ventricular ejection fraction. With a decrease in LVEF of the 3rd degree and below, as well as in cases where the permissible limit of the norm is reduced, the treatment with Lapatinib must be stopped. You can resume therapy after 2 weeks and at a lower dose, which will be 1000 mg / day at the same time as 1250 mg / day of the aromatase inhibitor and only when the relevant indicators are normalized. Buy Lapatinib directly from India without intermediaries. Price Lapatinib from India from manufacturer.
Therapy is discontinued in the development of Lapatinib and interstitial lung disease / pneumonitis (grade 3 and above) with the development of toxic effects of grade 2 and above. Therapy can be resumed only with a decrease in the severity of toxic effects (1st degree and lower). If the toxic effects appear later, the dose of the drug is reduced to 1000 mg / day while taking capecitabine and to 1250 mg / day - an aromatase inhibitor.
In patients with severely impaired liver function, Lapatinib is used with caution. The daily dose can be reduced to 750 mg and 1000 mg, respectively. If, while fulfilling these conditions, hepatotoxicity does occur, Lapatinib should be discontinued. Further use of the drug when it is impossible.
There is no indication of the use of Lapatinib in patients with impaired renal function.
The need for dose adjustment occurs during the development of a third degree of diarrhea in a patient, as well as a 1-2nd with complications. If a patient develops grade 4 diarrhea, Lapatinib a should be discontinued.
The simultaneous use of Lapatinib a and inhibitors or inducers of the CYP3A4 isoenzyme (itraconazole, ketoconazole, grapefruit juice) requires caution, since this combination can increase or decrease the risk of systemic exposure to the active ingredient of the drug. Buy Lapatinib Price Lapatinib India