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Cizumab (Bevacizumab 100mg / 4ml)

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Bevacizumab is a generic form of brand name Cizumab necessary for the anti-cancer medication, which belongs to a group of drugs knowns as monoclonal antibodies. An antibody is a molecule produced by the body in response to a foreign antigen. A monoclonal antibody is made in the laboratory to target and prevents certain proteins. These agents are very essential for the molecules which they are formed against and are therefore called targeted therapies.

Cizumab indication

Cizumab is indicated for the treatment of following conditions;

  • Metastatic colon or rectal cancer
  • Non-squamous, non-small cell lung cancer
  • Glioblastoma
  • Metastatic renal cell cancer
  • Metastatic cervical cancer:
  • Epithelial ovarian, fallopian tube or peritoneal cancer:

Cizumab pharmacology

Mechanism of action

Bevacizumab consist on targets a cancer cell protein called vascular endothelial growth factor (VEGF). This protein helps cancers to develop blood vessels, so they can have food and oxygen from the blood. All cancers require a blood supply to be able to survive and develop.

Bevacizumab stops this protein and inhibits the cancer from growing blood vessels, so it is macerated and can't grow. Treatments that prohibits the development of a blood supply are called anti-angiogenesis treatments.


The pharmacokinetic form of Cizumab is assayed by measuring total serum Bevacizumab concentration.


The volume of distribution is 2.9 (22%) L


The terminal half-life period of Bevacizumab is 20days (11 to 50days)

Cizumab dosage and administration

Key point: Cizumab do not administered before at least 28 days following surgery and the wound is completely cured

Non-small cell lung cancer

The usual dosage of Cizumab is 15mg/kg IV for every 3 weeks by co administration with carboplatin and paclitaxel

Metastatic colorectal carcinoma

The usual dosage of Cizumab by combination with 5-fluorouracil based chemotherapy

  • 5mg/kg of Cizumab for every 2 weeks IV in concomitant with bolus IFL
  • 10mg/kg of Cizumab for every 2 weeks IV in combination with FOLFOX4
  • 5mg/kg IV Cizumab for every 2 weeks or 7.5 mg/kg Cizumab as IV every 3 weeks by concurrently used with fluoropyrimidine Irinotecan or fluoropyrimidine oxaliplatin based therapy


The usual dose is 10mg/kg of Cizumab administered IV for every 2 weeks

Epithelial ovarian, fallopian tube or peritoneal cancer

Platinum opposing:

The usual dosage of Cizumab; 10mg/kg of Cizumab for every 2 weeks by combination with paclitaxel, pegylated liposomal doxorubicin or topotecan


The usual dosage of Cizumab; 15mg/kg of Cizumab given through IV for every 3 weeks by combining with topotecan

Platinum responsive

The recommended dosage of Cizumab; 15mg/kg given IV for 3 weeks in concomitant with carboplatin and paclitaxel for 6 to 8 cycles

The recommended dosage of Cizumab; 15mg/kg of Cizumab given IV for 3 weeks by combining with gemcitabine & carboplatin for 6 to 10 cycles

Metastatic renal cell cancer

The recommended dosage of Cizumab is 10mg/kg IV for every 2 weeks by concomitant use with interferon alfa

Metastatic cervical cancer

The usual dosage of Cizumab; 15mg/kg of Cizumab given intravenously for every 3 weeks by concomitant with paclitaxel and cisplatin or with paclitaxel and topotecan

Preparation & administration

Cizumab used as  intravenous solution

At initial infusion: given IV infusion over 90 minutes

Following infusions: give second infusion over 60 minutes, if tolerated

Administer all following infusion over 30minutes

Cizumab IV infusion is prepared in aseptic condition

Cizumab 400mg containing 16ml solution whereas 100mg containing 4ml

Cizumab dilute into 100ml of 0.9% NS

Do not dilute with dextrose solution

Discard the remaining portion which is left in a vial

Side effects

  • Venous thromboembolic events
  • Hypertension
  • Posterior reversible encephalopathy syndrome
  • Gastrointestinal perforation and fistulae
  • Surgery and wound healing complication
  • Hemorrhage
  • Arterial thromboembolic events
  • Renal injury & Proteinuria
  • Infusion reactions
  • Ovarian failure
  • Congestive heart failure
  • Neutropenia,
  • Mucosal inflammation,
  • Infection,
  • Neuropathy,
  • Epistaxis,
  • Erythrodysesthesia

Drug interaction

While concomitant use of Cizumab with paclitaxel & carboplatin, causes reduces in exposure of paclitaxel after four cycles of therapy

While getting patients with paclitaxel & carboplatin leads to raises the paclitaxel exposure at day 6


No contraindication occurred


Caution with use in the conditions like

Surgery and wound healing complications observes while Administration may result in the development of fatal wound dehiscence. Discontinue treatment in patients with wound dehiscence requiring medical intervention.

Serious or lethal hemorrhage, haemoptysis, gastrointestinal bleeding, hematemesis, CNS hemorrhage, and vaginal bleeding are increased in bevacizumab-treated patients. Do not administer the drug along with severe hemorrhage.

Severe, sometimes lethal, arterial thromboembolic events (ATE) involving cerebral infarction, transient ischemic attacks, myocardial infarction, angina, and a variety of other ATE; discontinue bevacizumab for severe ATE

Due Cizumab may have high relative risk for heart failure has been along with therapy

Advise females of reproductive possible to use active contraception during treatment with and for 6 months after the final dose


Pregnancy category: D

Cizumab may cause fetal harm to infants based on findings from animal studies and mechanism of action. The drug produces malformation while using during pregnancy.


Excretion into human breast milk is unknown. Breast feeding is also not recommended


Cizumab vial should be stored at 2 to 8oC (36 to 46oF)

Single use vial and protect from light

Do not freeze or shake the vial

Missed dose

If patient missed to have the dose or forget the cycle means must consult with oncologist and follow the regular dosing schedule

Do not take overdose. Consult the doctor immediately

  • Trade name Cizumab
  • Substance Bevacizumab 100mg / 4ml
  • Manufacturer Hetero Drugs Limited
  • Packaging 400mg of Bevacizumab containing a vial
  • Country of origin India
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