Crizalk 200mg (Crizotinib)
Crizalk 200mg belongs to type of tyrosine kinase inhibitor.
A kinase is an enzyme whichhelp to cell growth. There are many types of kinases, which regulates different phases of cell growth. By stopping an enzyme from working, this medication can reduce the growth of cancer cells.
Crizalk200mg is a prescription drug which is used under supervision of medical oncologist.
Crizalk 200mg is used for treatment in patients who suffering from locally advanced or metastatic non-small cell lung cancer (NSCLC) which is anaplastic lymphoma kinase-positive as detected by an FDA-approved test
Crizalk 200mg is also used for metastatic NSCLC tumors that are ROS1-positive
Mechanism of action
Crizotinib is an inhibitor of various receptor tyrosine kinases, consist of ALK and ROS1. It only works in cancer cells which have an overactive version of ALK or ROS1.
If NSCLC with genetic defects(rearrangements) in the ALK gene, a formation of ALK fusion proteins results in abnormal activation and signaling. This, in turn, supports the replication and survival of tumors which express these fusion proteins.
Crizotinib belongs to a potent inhibitor of ALK phosphorylation and signal transduction. This prevention was observed in preclinical and clinicalstudies to be analogue with cell cycle arrest and the initiation of programmed cell death in ALK-positive cancer cells.
Peak plasma concentration is 4 to 6 hours and bioavailability were 43%.
Volume of distribution is 1772L and plasma protein bounding is 91%
Crizalk metabolised by CYP3A4 and CYP3A5
Crizalk is excreted via feces 63% and 22% via urine and half -life is 42 hours
Dosage and administration
Some patients are selected for the treatment with Crizalk based on ALK or ROS1 presences in tumor specimens
The prescribed dosage of Crizalk is 250mg orally twice in a day
Administer the Crizalk dose with or without food, until disease progression
The capsule Crizalk should be swallowed whole.
Crizalk should not break, open, or chew the capsule.
Crizalk 200 mg taken orally twice daily for First dose reduction
Crizalk 250 mg taken orally once daily for Second dose reduction
Permanently discontinue if unable to tolerate Crizalk 200mg taken orally once daily.
- Feeling sick
- Swelling of hands and feet’s
- Decreased appetite
- Infection increased
- Eyesight changes
- Bowel changes
- Liver changes
- Skin rash
Interaction of Crizalk 200mg with strong or moderate CYP3A4 inhibitors will raise plasma concentration of Crizalk
Crizalk 200mg concomitant use with strong CYP3A inducers will reducesCrizalk plasma concentration
Crizalk 200mg Co administration with CYP3A substrates will increase plasma concentration of CYP3A substrates
Do not use combination with bradycardia causing drugs
Before using Crizalk 200mg in some condition, consult with doctor.
When administrating Hepatotoxicity resulted, increase in ALT and total bilirubin resulted, regulate q2wk for 2 months, then monthly
Interstitial lung disease/pneumonitis is reported while using the drug
QT interval prolongation resulted, do not use congenital long QT syndrome.
Symptomatic bradycardia resulted, involving syncope; do not use Crizalk 200mgcoadministration with other drugs known to cause bradycardia; monitor heart rate and blood pressure regularly
Severe visual loss is reported
Embryo-fetal toxicity will occur while administrating Crizalk 200mg to pregnant women.
Based on studies of animal and mechanism of action, Crizalk 200mg will cause fetal harm when given to pregnant women
Advice the female not to become pregnant while on treatment with Crizalk 200mg
During treatment with Crizalk 200mg, advise the women not to breastfed to infants
Stored at 200C – 250C
If the patient vomits after taking a dose of Crizalk 200mg or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose.
- Trade name Crizalk 200mg
- Substance Crizotinib
- Manufacturer Pfizer Ltd
- Packaging 60 capsules
- Country of origin India