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Pomyelo 4mg (Pomalidomide )

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POMYELO 4MG

POMYELO 4MG REFER AS

Pomyelo 4mg is an antineoplastic drug, which is used by the patients who are having a valid prescription and under the supervision of medical oncologist.

Pomyelo 4mg affects the immune system. It encourages immune responses to help reduce tumor growth.

POMYELO 4MG THERAPEUTIC INDICATIONS

The primary indication of Pomyelo 4mg is used in the treatment of Multiple Myeloma condition.

In this condition, Pomyelo 4mg is used by interaction with dexamethasone.

Pomyelo 4mg capsules are indicated in Patients already got therapy with two medications such as proteasome inhibitor & Lenalidomide. followed within 60 days in patients who are concluded the last treatment.

DOSAGE OF POMYELO 4MG

Pomyelo tablets are available in the strength of 1mg, 2mg and 4mg

In adults

Pomalidomide is a thalidomide analogue; it is used in combination with dexamethasone

The recommended dose of Pomyelo tablets in multiple myeloma condition, 4mg should be taken orally as a single dose on days 1-21 of repeated 28 days cycles until disease advancement

Pomyelo given in combination with low dose of dexamethasone

Dexamethasone should be given orally only in days of 1, 8, 15 and 22 of each 28 days

>75 years: 20mg/day

≤75 years: 40mg/day

Dose modification:

Pomalidomide therapy should be discontinue, if toxicities occur after dose reduction to 1mg (in case of neutropenia and thrombocytopenia)

In pediatric

<18 years: the safety and efficacy of the Pomyelo tablets has been established

Administration

Pomyelo tablets should be taken with water; it should not chew, break or open

Pomyelo should be taken with or without food

With strong CYP1A2

Pomyelo combined with CYP1A2 substrates causes increasing the plasma concentration of Pomalidomide and leads to elevate the risk of Pomalidomide.

OVER DOSAGE

No specific antidote is used for over dosage of Pomalidomide. Patient should be provided with general supportive measures. Monitor the signs & symptoms

SIDE EFFECTS OF POMYELO 4MG

  • Difficult, frequent, or painful urination
  • pale skin
  • rash, itching, hives
  • nosebleed
  • GIT problems: constipations, diarrhea, nausea, vomiting
  • Life changes: decrease appetite, weight changes, uncontrollable shaking of a part of the body, night sweats
  • Anxiety
  • Insomnia
  • Arthralgia, myalgia
  • swelling of the eyes, face, tongue, throat, hands, arms, feet, ankles, or lower legs
  • difficulty breathing or swallowing
  • hoarseness
  • fever, sore throat, chills, cough, or other signs of infection
  • yellow eyes or skin
  • dark urine
  • pain or discomfort in the right upper stomach area

POMYELO 4MG DRUG INTERACTION

Pomyelo 4mg combination with CYP1A2 drugs causes increased concentration of Pomalidomide.

Overcome this problem by decreasing the dose of Pomyelo 4mg during this combination therapy.

POMYELO 4MG WORKS AS

Thalidomide associate which evoke immunomodulatory and antineoplastic activity; it prohibits replication and induced apoptosis of hematopoietic tumor cells

Additionally, it increases T-cell and natural killer cell-mediated immunity and restrain production of TNF-alpha and interleukin-6; down-modulates cell surface adhesion molecules contain in leukocyte migration.

Anticancer activity may be due to inhibition of angiogenesis

Pomyelo 4mg ADME properties

Absorption: The peak plasma concentration time of Pomalidomide is arrives between 2 to 3 hours.

Distribution: Pomalidomide is bounded to human plasma protein by range of 12% & 44%.

Metabolism: The metabolism of Pomalidomide is appears via hepatically mediated through CYP1A2, CYP3A4.

Elimination: The Pomalidomide clearance value is 7 to 10L/hr.

Doses are excreted via urine 73% & feces 15% respectively.

Doses are excreted as in unchanged form through urine 2% & feces 8%.

The half-life period of Pomalidomide is 9.5 hours

POMYELO 4MG CONTRAINDICATION

Pomyelo 4mg is contraindicated to;

Pregnancy

Lactation

Hypersensitivity reactions produced due to patients are contraindicated to the component of Pomyelo 4mg.

SAFETY PRECAUTIONS

  • During Pomyelo 4mg treatment, there is a possibility of elevation of hepatic enzymes occurs. This may have reported as increased liver toxicity.
  • Pomyelo 4mg should not be used during pregnancy will causes Teratogenicity, organogenesis and causes fetal damage. Do not becoming pregnant during Pomyelo 4mg treatment by using effective contraceptives.
  • Deep vein thrombosis is harm while occurs during the Pomyelo 4mg Thromboprophylaxis is started for this condition. Increase of mortality in case of pembrolizumab taken with thalidomide & dexamethasone;
  • Neutropenia, thrombocytopenia is main common side effects occur during the Pomyelo 4mg These may counteract by checking the blood counts frequently and postponement of dosage or adjustment of dose is necessary.
  • Instruct the patients to keep away from circumstances where unsteadiness or disturbed state might be an issue and not to take different meds that may leads to dazedness or disturbed state without adequate therapeutic exhortation.

POMYELO 4MG USES IN

Pregnancy

Pregnancy category of Pomyelo 4mg is X. Pomyelo 4mg usage during pregnancy period, leads to fetal harm and causes death.

Lactation

Breast feeding should not be recommended.

POMYELO 4MG STORAGE CONDITION

The Pomyelo 4mg capsules container should be stored at 20oC to 25oC

Protect the container from moisture, heat, & light.

MISSED DOSE

If missed dose occurs, consult with physician & follow the regular dosing schedule. Or skip the missed dose and follow the routine timing. Otherwise Missed dose leads to over dosage condition.

  • Trade name Pomyelo 4mg
  • Substance Pomalidomide
  • Manufacturer Intas Pharmaceuticals
  • Packaging 21 capsules
  • Country of origin India
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