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Zelgor 500mg (Abiraterone acetate)

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ZELGOR 500MG

Description

Zelgor 500mg is a derivative of androstane, which involves in the prohibition process of steroid 17 alpha-hydroxylase and containing anti-neoplastic activity and it is an oral tablet which is an active acetate ester form of a steroidal compound known as Abiraterone with anti-androgenic activity.

Indication of Zelgor 500mg

The Zelgor 500mg tablets are indicated for;

Metastatic castration resistance prostate cancer

Metastatic high-risk castration sensitive prostate cancer

Mechanism of Zelgor 500mg

Abiraterone acetate is a prodrug form, after oral administration which get converted into Abiraterone inside the body

Abiraterone, an active form which expels its action on androgen biosynthesis by prohibiting an enzyme called 17 alpha hydroxylase/C17, 20-lyase (CYP17).

This enzyme is important for androgen biosynthesis which is expressed in testicular, adrenal & prostatic cancer cells.

A CYP17 enzyme activates two consecutive reactions;

  1. Transformation of pregnenolone & progesterone to their 17 alpha hydroxy derivatives with the help of 17 alpha hydroxylase.
  2. Production of dehydroepiandrosterone & androstenedione, relatively by CYP17, 20 lyase activity.

DHEA & androstenedione are androgens which as messenger of testosterone.

Absorption

High plasma concentration of Zelgor 500mg is reaches within 2 hours after drug intake.

Food should not be taken for at least 2 hours earlier the dose of Zelgor 500mg or at least one hour after the dose of Zelgor 500mg.

Distribution

Zelgor 500mg is highly bound to human plasma protein with >99%.

Metabolism

Abiraterone acetate is undergone hydrolysis and leads to change into Abiraterone which an active form is.

Two major circulating metabolites of Abiraterone is;

Abiraterone sulphate

N-oxide Abiraterone sulphate

Excretion

88% of metabolite is excreted through feces; 5% in urine.

The component present in feces is an unchanged form of Abiraterone.

The terminal means half-life of Zelgor 500mg is 12 ± 5 hours.

Dosage and administration

In Metastatic CRPC:

The recommended dose of Zelgor is 1000mg (two 500 mg tablets or four 250 mg tablets) should be administered as a once daily with 5mg of prednisolone should be given two times a day

In Metastatic high risk CSPC:

The recommended dose of Zelgor is 1000mg (two 500 mg tablets or four 250 mg tablets) should be administered as a once daily with 5mg of prednisolone should be given two times a day

Dose modification:

In liver impairment patients:

In moderate hepatic damage patients, the dose of Zelgor should be reduced to 250mg as a single dose.

In moderate liver damaged patients, AST & ALT level should be monitored frequently.

In severe liver damaged patients, Zelgor should not be recommended.

Hepatotoxicity:

Patient suffered with liver toxicity, during the treatment Zelgor 500mg should be postponed and provide supportive measures.

Therapy should be resumed at reduced dose of 750mg as a single dose.

If liver toxicities reappear with the dose of 750mg, should be retreated with 500mg single dose followed with LFT.

Discontinue the Zelgor therapy permanently, if patients may have current elevation of AST & ALT.

Concurrent use of Zelgor 500mg with CYP3A4 inducers:

In case concurrent use of Zelgor 500mg with CYP3A4 inducers, the frequency of Zelgor 500mg tablets should be increased to two times a day, it may only occur in co administration time.

If co administration discontinues, then frequency changes to once daily.

Zelgor 500mg tablet should be administered on an empty stomach and food not taken for at least 2 hours before the dose or 1 hour after the dose.

Overdosage

The over dose of Zelgor 500mg has no specific antidote. Provide supportive measures and Monitor the patients for arrhythmia, cardiac failure & determines liver function to reduce the liver injuries.

Zelgor 500mg caused side effects

  • Hypertension
  • Diarrhea
  • Vomiting
  • Cough
  • Hypertension
  • Dyspnea
  • Urinary tract infection
  • Fatigue
  • Joint pain, swelling or discomfort
  • Hot flush
  • Contusion

Lab abnormalities:

  • Hypertriglyceridemia
  • Lymphopenia
  • Hypercholesteremia
  • Hyperglycemia
  • Increased AST, AST
  • Hypophosphatemia
  • Hypokalemia
  • Anemia
  • Increasing alkaline phosphatase

Post marketing reports:

  • Noninfectious pneumonitis
  • Myopathy, involving rhabdomyolysis
  • Fulminant hepatitis, acute hepatic failure leads to death

Drug- drug interaction

Avoid the concomitant use of CYP2D6 substrate with Zelgor 500mg.

In interaction of Zelgor 500mg with pioglitazone, causes increasing the systemic exposure of pioglitazone.

Co administration of Zelgor 500mg with CYP3A4 inducers like rifampin, causes reduction in the exposure of Abiraterone.

To avoid this condition, increases the dose of Zelgor 500mg for reducing the problems.

Zelgor 500mg is an inhibitor of CYP2D6 & CYP2C8, when administering 30mg of dextromethorphan with Zelgor 500mg 100mg & 5mg of prednisolone causes increasing the AUC &Cmax of dextromethorphan (CYP2D6 substrate).

Contraindications caused

Zelgor 500mg is contraindicated to pregnant & lactating women

Hypersensitivity reactions may occur due to patients is contraindicating to the component present in the Zelgor 500mg tablets.

Precautions and warning

Hypertension, hypokalemia & fluid retention:

Zelgor 500mg inhibits CYP17, causes increasing the mineralocorticoid levels leads to hypokalemia, hypertension & retention of fluids.

Concurrent use of Zelgor 500mg with corticosteroid leads to diminish adrenocorticotrophic hormone which concludes as reduction in extent & harshness of these adverse effects.

 Control the blood pressure and correct the level of potassium and fluids if required.

Adrenocortical insufficiency:

Adrenocortical deficiency occurs during the therapy of Zelgor 500mg with prednisolone.

In this condition, treatment should be interrupt or discontinue.

Monitor the signs & symptoms occurred due to this condition.

Elevation of dose of corticosteroids occurs in both before and during the treatment.

Hepatic toxicities:

In post marketing studies, due to Zelgor 500mg therapy hepatic toxicity may occur due to acute hepatic injury leads to death.

Increasing AST, bilirubin, ALT may lead to this condition.

Patients may undergo Hepatic function test frequently before or during the treatment.

Pregnancy and lactation

Pregnancy category: X

Zelgor 500mg should not be used in pregnancy condition

Breast feeding should not be allowed.

The potency of Zelgor 500mg tablets has not been evaluated in pediatric patients.

No drug safety evaluated in geriatric patients above 65 years of age.

Storage and handling

Store Zelgor 500mg tablet container should be at 20oC to 25oC

Protect the drug free from moisture, heat & light

Missed dose

Take the missed dose before next dose time reaches or Missed dose of Zelgor 500mg tablets should be avoided.

Consult with medical oncologist and follow the instructions

Follow the regular dosing schedule

  • Trade name Zelgor 500mg
  • Substance Abiraterone acetate
  • Manufacturer Sun Pharma
  • Packaging 60 tablets
  • Country of origin India
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